|
KMID : 0614620150660040215
|
|
Korean Journal of Gastroenterology
2015 Volume.66 No. 4 p.215 ~ p.220
|
|
|
MicroRNA-200c as a Prognostic Biomarker for Pancreatic Cancer
|
|
백우현:Paik Woo-Hyun
송병준:Song Byeong-Jun/김형우:Kim Hyoung-Woo/김혜리:Kim Hye-Ree/황진혁:Hwang Jin-Hyeok
|
|
|
Abstract
|
|
|
Background/Aims: MicroRNA (miRNA) regulates messenger RNA stability and translation. In cancer biology, miRNA affects the growth and metastasis of cancer cells by controlling epithelial-mesenchymal transition (EMT). MiR-200 family (200a/200b/ 200c/141) and miR-205 are associated with the regulation of EMT. We investigated the prognostic role of EMT-related miRNAs in pancreatic cancer.
Methods: We analyzed miR-200 family and miR-205 expression in tissue samples of 84 patients who underwent radical resection for pancreatic cancer.
Results: Patients were followed from the date of diagnosis until death or censoring. The mean overall survival was 25.0±2.0months (2-140 months). The R0 resection rate was obtained in 84.5% (n=71) of patients. The relative expressions of miR-200a/200b/200c/141 and miR-205 were 266.9±57.3/18.5±2.2/0.7±0.1/27.2±6.6 folds and 0.1±0.1 compared with human pancreatic ductal epithelial cells, respectively. Overall survival was longer in the low miR-200c expression group than in the high expression group (35 vs. 19 months, p=0.013). Multivariate analysis confirmed that patients with low miR-200c expression survived longer than the high expression group (hazard ratio, 1.771; 95% CI, 1.081-2.900; p=0.023). There was a trend toward longer disease-free survival in low miR-200c group without statistical significance (p=0.061).
Conclusions: The expression of miR-200c may be an important prognosis factor in pancreatic cancer, and it could be a novel therapeutic target of pancreatic cancer.
|
|
|
KEYWORD
|
|
|
Pancreatic neoplasms, MicroRNAs, Epithelial-mesenchymal transition, MIRN200 microRNA, Human
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|